Clinical Characteristics of 606 Patients with Community-Acquired Pyoge & More Trending News



Pyogenic liver abscess (PLA) is an infectious illness attributable to pyogenic micro organism invading the liver by way of numerous channels, accounting for 13% of belly infectious ailments and 48% of visceral abscesses.1,2 In latest years, the general incidence price of PLA has been growing progressively, and the incidence price is increased in Asian nations.3–5 In the previous 20 years, the an infection price of Klebsiella pneumoniae (Okay. pneumoniae) within the Asian inhabitants has progressively elevated. At current, it has change into the principle pathogen inflicting PLA an infection.6–8 Patients with PLA could have nonspecific manifestations resembling chills, fever, shivers, and ache within the liver space. When the an infection is poorly managed, PLAs, particularly these attributable to Okay. pneumoniae, can result in sepsis, a number of organ dysfunction, and dying; it has a mortality price of 2%–31%.9 However, because of the nonspecific manifestations of some sufferers, there are some misdiagnoses and missed diagnoses in clinics. To enhance the analysis price of PLA within the native space, efficient empirical therapy should start as quickly as potential to enhance the prognosis of sufferers. The choice of antimicrobial medication requires the mix with native PLA pathogenesis and medical manifestations. In this retrospective research, we aimed to investigate the medical traits, etiological traits, drug resistance, and empirical use of antibiotics for community-acquired pyogenic liver abscess (PLA), and subsequently to offer a foundation for rational and efficient empirical therapy of PLA within the native space.

Data and Methods


PLA met the diagnostic standards proposed by Foo et al10 in 2010. Exclusion standards: (1) combined an infection, mixed with fungal or parasitic an infection; (2) the pathogenic tradition outcomes of the identical affected person weren’t the identical; (3) the tradition outcomes have been thought-about as contaminated micro organism. The research was accredited by the ethics committee of the hospital.

Research Methods

A complete of 606 sufferers with PLA, identified in Yantai Yuhuangding Hospital from 2015 to 2020, have been analyzed retrospectively. The fundamental knowledge, laboratory outcomes, microbiological outcomes, and therapy strategies (eg, empirical anti-infective remedy scheme and drainage) have been collected.

Result Interpretation Criteria

The healing impact was evaluated after two weeks of hospitalization. (1) Effective: the signs have been relieved, and the abscess shrunk after therapy. (2) Ineffective: the signs weren’t alleviated or worsened after therapy, the scale of the pus cavity didn’t change, will increase upon imaging examination (belly ultrasound, computed tomography [CT] or magnetic resonance imaging) have been famous, or the dying of the affected person.

Bacterial Isolation and Culture

Culture of Drainage Fluid and Blood

The affected person’s ultrasound-guided percutaneous drainage fluid was instantly despatched to the bacterial room for tradition. An inoculating nutrient broth was used to extend the quantity of the micro organism. After 24 h, the micro organism have been transferred to a blood plate and a MacConkey agar plate on the similar time and cultured at 35°C for twenty-four h. A blood tradition was carried out in strict accordance with the related strategies within the BACTEC9050 blood tradition person handbook. After the constructive alarm of the LED show display screen of the instrument, smearing and seed transfers have been carried out on the similar time. The technique of seed switch is similar as that of bizarre tradition. For the pus tradition, the pus was immediately inoculated in a blood plate and a MacConkey agar plate and cultured at 35°C for twenty-four h.

Pathogen Identification and Drug Sensitivity Test

The separated micro organism have been dissolved evenly within the identification tradition medium. The turbidimeter was used to regulate the turbidity (0.5 Michaelis turbidity), and 25 μL of the pattern was taken from the dissolved identification tradition medium into the drug sensitivity inoculation tradition medium and positioned within the corresponding effectively of the constructive plate or destructive plate. A full-automatic microbial analyzer, with its personal bacterial identification/drug sensitivity system, was used for pathogen identification and drug sensitivity detection.

Statistical Analysis

The authentic knowledge of the sufferers have been collected and sorted with Excel. The knowledge have been statistically analyzed utilizing statistical software program SPSS 22.0. Normally distributed and roughly usually distributed measurement knowledge have been expressed because the imply ± commonplace deviation and in contrast between teams utilizing t-tests. Non-normally distributed measurement knowledge have been expressed because the median and interquartile and in contrast between teams utilizing non-parametric checks. The depend knowledge have been expressed as numbers (proportion) and in contrast utilizing two unbiased pattern Chi-square checks or Fisher actual likelihood strategies. P < 0.05 was thought-about statistically important.


Basic Data of Patients with PLA

Of the 606 sufferers with PLA, 345 have been males (56.7%), with a male-to-female ratio of 1.3:1. The age vary of these sufferers was 18–97 years, with a median age of 60.3 ± 14.1 years. The most important underlying ailments have been diabetes, cerebrovascular illness, and benign biliary illness, accounted for 38.7%, 27.9%, and 22.3% respectively (Table 1).

Table 1 Clinical Features of Pyogenic Liver Abscess

Clinical and Laboratory Data of PLA

Clinical Manifestations

Fever (563 sufferers, 92.9%) was the most typical medical manifestation, adopted by chills and chills (74.7%). Of all sufferers, 323 had a peak physique temperature of >39°C, accounting for 57.3% of the sufferers with fever. Abdominal ache was a medical manifestation in 44.7% of sufferers, 33.3% had vomiting or nausea, 18.2% had fatigue and poor urge for food, and 6.3% had jaundice. Some sufferers had different atypical medical signs (Table 1).

Laboratory Tests

Elevated leukocytes have been present in 408 sufferers (68.5%). There have been 76.8% of the sufferers with elevated neutrophils; 289 (99.0%) of them had elevated C-reactive protein; and 202 (76.5%) had elevated procalcitonin. Other widespread irregular laboratory indicators have been as follows: 338 sufferers (56.8%) with anemia, 179 sufferers with albumin discount (30.2%), 423 sufferers (71.4%) with elevated γ-glutamyltransferase, 324 sufferers (54.7%) with elevated alkaline phosphatase, 301 sufferers (50.6%) with elevated alanine aminotransferase, 270 sufferers (45.4%) with elevated aspartate aminotransferase, 278 sufferers (47.2%) with elevated fasting blood glucose, and 462 (79.9%) sufferers with elevated lactate dehydrogenase.

Ultrasonic or CT Results

Of these 606 sufferers, 451 sufferers (74.4%) had a single abscess. In 406 sufferers (67%), the abscess was in the precise lobe.

Analysis of Etiological Characteristics of PLA

Blood cultures have been administered to 404 sufferers, and the constructive price was 26.1%. Among them, Okay. pneumoniae was dominant (79 sufferers, 74.5%), adopted by Escherichia coli (E. coli; 13 sufferers, 12.3%). Pus cultures have been carried out on 409 sufferers, and the constructive price was 69.4% (284 sufferers). Among them, Okay. pneumoniae was dominant (233 sufferers, 82.1%), adopted by E. coli (29 sufferers, 10.2%). The detection price of constructive cocci was very low in each the blood and pus cultures (Table 2).

Table 2 Results of Blood Culture and Pus Culture

Drug Resistance of Pathogens

In the 272 strains destructive for extended-spectrum β-lactamase (ESBLs), along with 100% resistance to ampicillin and fewer than 50% sensitivity to nitrofurantoin, their sensitivity to the generally used cephalosporins III, cephalosporins and monocyclic β-Lactams, quinolones (ciprofloxacin, levofloxacin), aminoglycosides (tobramycin, gentamicin, amikacin), tetracyclines (tigecycline) β-lactamase inhibitor compound (Cefoperazone/sulbactam, amoxicillin/clavulanic acid, piperacillin/tazobactam), and carbapenems was increased than 90%, whereas the sensitivity price to amikacin and meropenem was 100%. However, the susceptibility of Okay. pneumoniae to cotrimoxazole and levofloxacin was higher than that of E. coli.

Thirty-three ESBL (+) strains had increased than 80% sensitivity to carbapenems (imipenem, meropenem, ertapenem, and biapenem), tetracyclines (tigecycline), β-lactamase inhibitor compound (cefoperazone/sulbactam, piperacillin/tazobactam), and amikacin. Only two strains have been multidrug resistance and all of them have been E. coli (Table 3).

Table 3 Analysis of Drug Resistance of Enterobacteriaceae Bacteria

Empirical Anti-Infective Therapy

Of all sufferers, 228 have been empirically handled with β-lactamase inhibitor compound for anti-infection therapy, and the proportion was the very best (37.6%). Of the whole, 180 sufferers (29.7%) have been empirically handled with cephalosporin, and 180 sufferers (29.7%) have been empirically handled with carbapenems. In addition, 147 sufferers (24.3%) have been empirically handled with quinolones, and 135 sufferers (22.3%) have been handled with a single sort of antibiotic. The remaining sufferers have been handled with mixed anti-infective remedy (cephalosporins mixed with quinolones or aminoglycosides or nitroimidazoles, cefoperazone/sulbactam, or piperacillin/ sulbactam mixed with nitroimidazoles). In 75 sufferers (12.3%), the anti-infection therapy was efficient, and these sufferers underwent step-down therapy. A complete of 105 sufferers (17.3%) obtained an upgraded therapy of carbapenem anti-infection. In 60 (9.9%) of these sufferers, the therapy was upgraded to antibiotics as a result of of their critical situation, expertise, or poor anti-infection therapy impact in keeping with the drug sensitivity outcomes (Figure 1).

Figure 1 Empirical use of antibiotics.

Efficacy Evaluation of Different Treatment Methods

Of all sufferers, 154 have been handled with antibiotics alone and 452 have been handled with antibiotics mixed with puncture and drainage. Of the 154 sufferers handled with antibiotics alone, 143 sufferers (92.9%) achieved efficient outcomes, and 11 sufferers (7.1%) achieved ineffective outcomes. In the mixed therapy group, 423 sufferers (93.6%) achieved efficient outcomes, and 29 sufferers (6.4%) achieved ineffective outcomes. A comparability revealed that there was no important distinction within the efficacy between the 2 therapy strategies. However, the common size of the hospital stays of the sufferers who obtained mixed therapy was considerably shorter than that of the sufferers who have been handled with antibiotics alone (Table 4).

Table 4 Comparison of Curative Effect Between the Two Groups with Different Treatment Methods


Pyogenic liver abscess is a critical infectious illness that threatens human well being. It can develop right into a life-threatening extreme an infection in sufferers with immunodeficiencies and older sufferers with underlying ailments. This research revealed that PLA often happens in males (the male-to-female ratio was 1.3:1). The common age was 60.3 ± 14.1 years. These outcomes are constant with the outcomes of earlier research. The most important underlying ailments have been diabetes and biliary tract illness, just like these of earlier research. This is principally as a result of the liver has two units of blood provide, specifically the hepatic artery and the portal vein. The portal vein is related to the gastrointestinal tract, and sufferers with underlying ailments of the biliary tract and intestinal tract may have an elevated likelihood of an incidence of liver abscess.11–16 In this research, 563 sufferers with PLA (92.9%) had a fever as the principle medical symptom and 323 sufferers (57.3%) had a excessive fever (>39.0°C). This is principally constant with that reported in research each domestically and globally.17–19 Therefore, in sufferers with a fever of an unknown trigger, PLA ought to be fastidiously thought-about, particularly for sufferers with a excessive fever. Other medical signs of PLA will be jaundice, fatigue, poor urge for food, and fading consciousness, suggesting that the medical manifestation of PLA isn’t typical, so clinicians ought to be vigilant to keep away from misdiagnoses and missed diagnoses that delay the situation and have an effect on the prognosis. This research revealed that sufferers with a single bacterial an infection accounted for 93.0% of the sufferers. Among them, the detection price of Okay. pneumoniae was 73.1%, barely increased than that reported within the literature (64.0%).20 The cause for this can be associated to the sufferers’ underlying illness.21 The literature reported that diabetes mellitus was an unbiased danger issue for Okay. pneumoniae liver abscess.22 In this research, the proportion of diabetes within the underlying ailments was the very best.23 In our research, empirical anti-infection remedy was primarily compound β-lactamase inhibitor (36.0%), carbapenems (31.5%), and cephalosporins (31.3%). Singapore students studied sufferers with PLA with comparable fundamental knowledge handled with oral ciprofloxacin and injection of levofloxacin for 28 days. The outcomes revealed that there was no distinction within the therapy results between the 2 teams.24 Scholars in China’s Taiwan area revealed that25 there was no important distinction within the therapy impact of sufferers with PLA and even extreme an infection between quinolones and compound β-lactamase inhibitors. Quinolones also can shorten the time of administration of intravenous antibiotics and hospital keep. The cause could also be that the principle pathogen of PLA in China’s Taiwan area and Singapore is Okay. pneumoniae.

The limitation of this research also needs to be acknowledged. In phrases of the choice of empirical antibiotics, there was a scarcity of analysis of the efficacy of completely different antibiotics in sufferers with the identical fundamental knowledge. In future analysis, pairing analysis will likely be carried out to offer the idea for a extra affordable and efficient laboratory choice of antibiotics.


The current research revealed that empirical therapy of sufferers with community-acquired liver abscess with out danger components of ESBL an infection also needs to undertake compound β-lactamase inhibitors and even carbapenems. These findings could present a foundation for rational and efficient empirical therapy of PLA on this area.

Data Sharing Statement

All knowledge generated or analysed throughout this research are included on this article. Further enquiries will be directed to the corresponding creator.

Ethics Approval and Consent to Participate

The research was carried out in accordance with the Declaration of Helsinki (as was revised in 2013). The research was accredited by Ethics Committee of the Yuhuangding Hospital. Written knowledgeable consent was obtained from all contributors.


We are notably grateful to all of the individuals who have given us assistance on our article.


This research was supported by the Yantai Science and know-how innovation growth plan (2022YD015).


The authors declare that they don’t have any competing pursuits.


1. Chan DS, Archuleta S, Llorin RM, Lye DC, Fisher D. Standardized outpatient administration of Klebsiella pneumoniae liver abscesses. Int J Infect Dis. 2013;17(3):e185–e188. doi:10.1016/j.ijid.2012.10.002

2. Rahimian J, Wilson T, Oram V, Holzman RS. Pyogenic liver abscess: latest traits in etiology and mortality. Clin Infect Dis. 2004;39(11):1654–1659. doi:10.1086/425616

3. Fung CP, Chang FY, Lee SC, et al. A world rising illness of Klebsiella pneumoniae liver abscess: is serotype K1 an essential issue for classy endophthalmitis? Gut. 2002;50(3):420–424. doi:10.1136/intestine.50.3.420

4. Meddings L, Myers RP, Hubbard J, et al. A population-based research of pyogenic liver abscesses within the United States: incidence, mortality, and temporal traits. Am J Gastroenterol. 2010;105(1):117–124. doi:10.1038/ajg.2009.614

5. Horiguchi Okay, Tsurutani Y, Sasaki T, et al. Hypervirulent Klebsiella pneumoniae an infection in an aged affected person with diabetes mellitus. Geriatr Gerontol Int. 2021;21(7):590–591. doi:10.1111/ggi.14179

6. Tseng CW, Chen YT, Lin CL, Liang JA. Association between persistent pancreatitis and pyogenic liver abscess: a nationwide inhabitants research. Curr Med Res Opin. 2017;33(3):505–510. doi:10.1080/03007995.2016.1266312

7. Jepsen P, Vilstrup H, Schønheyder HC, Sørensen HT. A nationwide research of the incidence and 30-day mortality price of pyogenic liver abscess in Denmark, 1977–2002. Aliment Pharmacol Ther. 2005;21(10):1185–1188. doi:10.1111/j.1365-2036.2005.02487.x

8. Qian Y, Wong CC, Lai S, et al. A retrospective research of pyogenic liver abscess specializing in Klebsiella pneumoniae as a main pathogen in China from 1994 to 2015. Sci Rep. 2016;6:38587. doi:10.1038/srep38587

9. Santos-Rosa OM, Lunardelli HS, Ribeiro-Junior MA. PYOGENIC LIVER ABSCESS: DIAGNOSTIC AND THERAPEUTIC MANAGEMENT. Arq Bras Cir Dig. 2016;29(3):194–197. doi:10.1590/0102-6720201600030015

10. Foo NP, Chen KT, Lin HJ, Guo HR. Characteristics of pyogenic liver abscess sufferers with and with out diabetes mellitus. Am J Gastroenterol. 2010;105(2):328–335. doi:10.1038/ajg.2009.586

11. Chen N, Jin TT, Liu WN, et al. Gastric microbiota alteration in Klebsiella pneumoniae-caused liver abscesses mice. Pol J Microbiol. 2019;68(2):247–254. doi:10.33073/pjm-2019-026

12. Shi SH, Feng XN, Lai MC, Kong HS, Zheng SS. Biliary ailments as most important causes of pyogenic liver abscess attributable to extended-spectrum beta-lactamase-producing Enterobacteriaceae. Liver Int. 2017;37(5):727–734. doi:10.1111/liv.13267

13. Shi S, Xia W, Guo H, Kong H, Zheng S. Unique traits of pyogenic liver abscesses of biliary origin. Surgery. 2016;159(5):1316–1324. doi:10.1016/j.surg.2015.11.012

14. Chen SC, Lee YT, Yen CH, et al. Pyogenic liver abscess within the aged: medical options, outcomes and prognostic components. Age Ageing. 2009;38(3):271–276. doi:10.1093/ageing/afp002

15. Lok KH, Li KF, Li KK, Szeto ML. Pyogenic liver abscess: medical profile, microbiological traits, and administration in a Hong Kong hospital. J Microbiol Immunol Infect. 2008;41(6):483–490.

16. Shen DX, Wang J, Li DD. Klebsiella pneumoniae liver abscesses. Lancet Infect Dis. 2013;13(5):390–391. doi:10.1016/S1473-3099(13)70068-9

17. Serraino C, Elia C, Bracco C, et al. Characteristics and administration of pyogenic liver abscess: a European expertise. Medicine. 2018;97(19):e0628. doi:10.1097/MD.0000000000010628

18. Wang WJ, Tao Z, Wu HL. Etiology and medical manifestations of bacterial liver abscess: a research of 102 instances. Medicine. 2018;97(38):e12326. doi:10.1097/MD.0000000000012326

19. Liu L, Chen W, Lu X, Zhang Okay, Zhu C. Pyogenic liver abscess: a retrospective research of 105 instances in an emergency division from East China. J Emerg Med. 2017;52(4):409–416. doi:10.1016/j.jemermed.2016.09.026

20. Ruiz-Hernández JJ, León-Mazorra M, Conde-Martel A, Marchena-Gómez J, Hemmersbach-Miller M, Betancor-León P. Pyogenic liver abscesses: mortality-related components. Eur J Gastroenterol Hepatol. 2007;19(10):853–858. doi:10.1097/MEG.0b013e3282eeb53b

21. Lin L, Su LL, Li HH, et al. Study on high quality markers and motion mechanisms of inulae flos on anti-hepatitis by way of community pharmacology and high-performance liquid chromatography fingerprints. World J Tradit Chin Med. 2022;8:426–435. doi:10.4103/wjtcm.wjtcm_1_22

22. Kong H, Yu F, Zhang W, Li X. Clinical and microbiological traits of pyogenic liver abscess in a tertiary hospital in East China. Medicine. 2017;96(37):e8050. doi:10.1097/MD.0000000000008050

23. Li W, Chen H, Wu S, Peng J. A comparability of pyogenic liver abscess in sufferers with or with out diabetes: a retrospective research of 246 instances. BMC Gastroenterol. 2018;18(1):144. doi:10.1186/s12876-018-0875-y

24. Molton JS, Chan M, Kalimuddin S, et al. Oral vs intravenous antibiotics for sufferers with Klebsiella pneumoniae liver abscess: a randomized, managed noninferiority research. Clin Infect Dis. 2020;71(4):952–959. doi:10.1093/cid/ciz881

25. Chuang C, Chou SH, Wang FD, Huang YH, Tsai TH, Lin YT. Fluoroquinolones in its place therapy for Klebsiella pneumoniae liver abscess and affect on hospital size of keep. Int J Antimicrob Agents. 2020;56(4):106120. doi:10.1016/j.ijantimicag.2020.106120

Clinical Characteristics of 606 Patients with Community-Acquired Pyoge

I’ve made it my mission to maintain you recent on all the most recent happenings on the earth as of proper now, within the 12 months 2022, by means of this web site, and I’m sure that you will discover this to be an pleasant expertise. Regardless of what the newest information could should say, it stays a subject of intense curiosity.

It has at all times been our objective to speak with you and supply you with up-to-date information and details about the information free of charge. information about electrical energy, levels, donations, Bitcoin buying and selling, actual property, video video games, shopper traits, digital advertising and marketing, telecommunications, banking, journey, well being, cryptocurrency, and claims are all included right here. You preserve seeing our messages as a result of we labored arduous to take action. Due to the big variety of content material varieties, please don’t hesitate to

Clinical Characteristics of 606 Patients with Community-Acquired Pyoge

I’m sure you will discover the information I’ve ready and despatched out to be attention-grabbing and helpful; going ahead, we wish to embody contemporary options tailor-made to your pursuits each week.

data with out going by way of us first, so we are able to present you the most recent and biggest information with out costing you a dime. The two of you could study the specifics of the information collectively, supplying you with a leg up. We’ll get to the subsequent step when a little bit time has gone.

Our objective is to maintain you recent on all the latest information from across the globe by posting related articles on our web site, so that you could be at all times be one step forward. In this fashion, you will by no means fall behind the most recent developments in that information.

Clinical Characteristics of 606 Patients with Community-Acquired Pyoge

The information tales I’ve shared with you might be both fully authentic or will likely be fully authentic to you and your viewers. Moreover, I’ve made all of this knowledge accessible to each one of you, together with Trending News, Breaking News, Health News, Science News, Sports News, Entertainment News, Technology News, Business News, and World News, so that you could be at all times be within the know, at all times be one step forward of the state of affairs, and at all times get immediately’s information. The path that’s two steps forward of the present one ought to at all times be taken.

Read Entire Article?

Scroll to Top