US monthly costs for biosimilars ‘substantially higher’ than Germany or Switzerland, JAMA research finds – Endpoints News & More Trending News


As the glob­al bi­o­log­ics mar­ket is ex­pect­ed to hit close to­ly the half-tril­lion-dol­lar mark this yr, new JA­MA re­search factors to the im­por­tance of time­ly biosim­i­lar en­attempt, par­tic­u­lar­ly as few­er biosim­i­lars are en­ter­ing the US than in Eu­rope, and as month­ly deal with­ment costs for biosim­i­lars have been “sub­stan­tial­ly high­er” within the US com­pared with Ger­many and Switzer­land.

Among the three coun­tries, biosim­i­lar mar­ket share at launch was excessive­est in Ger­many, however in­creased on the quickest price within the US, the au­thors from the Uni­ver­si­ty of Zurich’s In­sti­tute of Law wrote in JA­MA Net­work Open to­day.

“In the US, up­take was high­est for be­va­cizum­ab (36%) and low­est for in­flix­imab (3%) 1 year af­ter mar­ket en­try,” they not­ed. “Up­take in Ger­many was high­est for adal­i­mum­ab (48%) [adal­i­mum­ab biosim­i­lars in the US don’t launch un­til next year] and low­est for in­sulin lispro (2%), where­as in Switzer­land, up­take was high­est for rit­ux­imab (25%) and low­est for in­sulin glargine (1%) 1 year af­ter mar­ket en­try.”

While not­ing that biosim­i­lar up­soak up­creased steadi­ly throughout all three coun­tries from 2011 to 2020, the research on­ly eval­u­at­ed 15 biosim­i­lars and 6 bi­o­log­ics for the US, 52 biosim­i­lars and 15 bi­o­log­ics for Ger­many, and 28 biosim­i­lars and 13 bi­o­log­ics for Switzer­land.

The rel­a­tive lack of ex­pe­ri­ence to date within the US, as the trail­method for biosim­i­lars wasn’t in­tro­duced within the US un­til 2012, al­so isn’t the trigger for the gaps in value be­tween the Eu­ro­pean coun­tries and the US.

Ker­stin Vokinger

“We al­so made a sub-analy­sis com­par­ing costs for biosim­i­lars and bi­o­log­ics ap­proved in all three coun­tries (see Fig 4B, page 6) and the re­sults hold,” co-au­thor Ker­stin Vokinger informed End­factors News. “Thus, the high­er costs can­not be ex­plained with the BP­CIA cre­at­ed in 2012.”

In the con­clu­sion, they referred to as for ne­go­ti­a­tions within the US to professional­hib­it ex­clu­sion­ary con­tracts in or­der to al­low biosim­i­lars to en­ter the mar­ket quickly­er and at low­er costs, “which could re­sult in low­er health­care costs and im­proved pa­tient ac­cess.”

The in­tro­duc­tion of in­ter­change­in a position biosim­i­lars might al­so be key to lev­el­ing the play­ing discipline and dri­ving down costs, FDA lead­ers mentioned re­cent­ly. Al­although on­ly 22 of 39 ap­proved biosim­i­lars have launched within the US, a re­cent re­port from Am­gen ap­prox­i­mates that they’ve cre­at­ed round $21 bil­lion in sav­ings over the past six years.

US monthly costs for biosimilars ‘substantially higher’ than Germany or Switzerland, JAMA research finds – Endpoints News

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US monthly costs for biosimilars ‘substantially higher’ than Germany or Switzerland, JAMA research finds – Endpoints News

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US monthly costs for biosimilars ‘substantially higher’ than Germany or Switzerland, JAMA research finds – Endpoints News

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